La ricerca scientifica
La nostra ricerca serve come riferimento per chi vuole approdondire ulteriori letture sull'argomento dei batteri, sulla salute umana e sulla scienza che si trova alla base dei nostri prodotti. Le fonti utilizzate sono elencate con tutte le informazioni. Questo offre una panoramica accurata della ricerca che utilizziamo.
Il microbioma
Panoramica
Revised estimates for the number of human and bacteria cells in the body.1
Diversity of the Human Intestinal Microbial Flora.2The gut microbiota-masters of host development and physiology.31. Sender, R., et al. (2016). Revised estimates for the number of human and bacteria cells in the body. PLoS biology, 14(8)
2. Eckburg, P. B., et al. (2005). Diversity of the human intestinal microbial flora. science, 308(5728), 1635-1638.
3. Sommer, F., & Bäckhed, F. (2013). The gut microbiota—masters of host development and physiology. Nature Reviews Microbiology, 11(4), 227.
... e le sue funzioni
Digestione
Gut microbiota and gastrointestinal health: current concepts and future directions.1
Gut microbiota functions: metabolism of nutrients and other food components.21. Aziz, Q., et al. (2013). Gut microbiota and gastrointestinal health: current concepts and future directions. Neurogastroenterology & Motility, 25(1), 4-15.
2. Rowland, I., et al. (2018). Gut microbiota functions: metabolism of nutrients and other food components. European journal of nutrition, 57(1), 1-24.
Rinforzo della barriera intestinale
Regulation of intestinal epithelial permeability by tight junctions.1
Policing the intestinal epithelial barrier: Innate immune functions of intraepithelial lymphocytes.21. Suzuki, T. (2013). Regulation of intestinal epithelial permeability by tight junctions. Cellular and molecular life sciences, 70(4), 631-659.
2. Hu, M. D., et al. (2018). Policing the intestinal epithelial barrier: innate immune functions of intraepithelial lymphocytes. Current pathobiology reports, 6(1), 35-46.
Sistema immunitario
Protective and Pro-Inflammatory Roles of Intestinal Bacteria.1
Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases.2The Intestinal Epithelium: Central Coordinator of Mucosal Immunity.3The microbiome and innate immunity.4
1. Webb, C. R., et al. (2016). Protective and pro-inflammatory roles of intestinal bacteria. Pathophysiology, 23(2), 67-80.
2. Tlaskalová-Hogenová, H., et al. (2004). Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunology letters, 93(2-3), 97-108.
3. Allaire, J. M., (2018). The intestinal epithelium: central coordinator of mucosal immunity. Trends in immunology, 39(9), 677-696.
4. Thaiss, C. A., (2016). The microbiome and innate immunity. Nature, 535(7610), 65.
Metabolismo
Effectiveness of probiotics in type 2 diabetes: a meta-analysis.1
Conserved Shifts in the Gut Microbiota Due to Gastric Bypass Reduce Host Weight and Adiposity.2
1. Kasińska, M. A., & Drzewoski, J. (2015). Effectiveness of probiotics in type 2 diabetes: a meta-analysis. Pol Arch Med Wewn, 125(11), 803-813.
2. Liou, A. P., et al. (2013). Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity. Science translational medicine, 5(178), 178ra41-178ra41.
Produzione di metaboliti
Finding the Missing Links among Metabolites, Microbes, and the Host.1
Impact of dietary gut microbial metabolites on the epigenome.2
1. Dorrestein, P. C., et al. (2014). Finding the missing links among metabolites, microbes, and the host. Immunity, 40(6), 824-832.
2. Gerhauser, C. (2018). Impact of dietary gut microbial metabolites on the epigenome. Philosophical Transactions of the Royal Society B: Biological Sciences, 373(1748), 20170359
Produzione di vitamine
B‐Group vitamin production by lactic acid bacteria – current knowledge and potential applications.1
Bacteria as vitamin suppliers to their host: a gut microbiota perspective.2
1. LeBlanc, J. G., et al. (2011). B‐Group vitamin production by lactic acid bacteria–current knowledge and potential applications. Journal of applied microbiology, 111(6), 1297-1309.
2. LeBlanc, J. G., et al. (2013). Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Current opinion in biotechnology, 24(2), 160-168.
Produzione di neurotrasmettitori
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis.1
1. Yano, J. M., et al. (2015). Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell, 161(2), 264-276.
Influenze ambientali
L'influenza dell'antibiotico sul microbioma
1. Langdon, A., et al. (2016). The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation. Genome medicine, 8(1), 39.
2. Dethlefsen, L., & Relman, D. A. (2011). Incomplete recovery and individualized responses of the human distal gut microbiota to repeated antibiotic perturbation. Proceedings of the National Academy of Sciences, 108(Supplement 1), 4554-4561.
3. Lange, K., et al. (2016). Effects of antibiotics on gut microbiota. Digestive Diseases, 34(3), 260-268.
4. Blaser, M. J. (2016). Antibiotic use and its consequences for the normal microbiome. Science, 352(6285), 544-545.
5. Jernberg, C., et al. (2007). Long-term ecological impacts of antibiotic administration on the human intestinal microbiota. The ISME journal, 1(1), 56.
L'influenza del sonno sul microbioma
1. Benedict, C., et al. (2016). Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals. Molecular metabolism, 5(12), 1175-1186.
2. Reynolds, A. C. et al. (2017). The shift work and health research agenda: considering changes in gut microbiota as a pathway linking shift work, sleep loss and circadian misalignment, and metabolic disease. Sleep medicine reviews, 34, 3-9.
L'influenza del fumo sul microbioma
1. Savin, Z., et al. (2018). Smoking and the intestinal microbiome. Archives of microbiology, 200(5), 677-684.
L'influenza della dieta sul microbioma
Influence of diet on the gut microbiome and implications for human health.1
Diet rapidly and reproducibly alters the human gut microbiome.2Nutrition meets the microbiome: micronutrients and the microbiota.3Diet and the intestinal microbiome: associations, functions, and implications for health and disease.4Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa5The role of diet in triggering human inflammatory disorders in the modern age.6Starving our Microbial Self: The Deleterious Consequences of a Diet Deficient in Microbiota-Accessible Carbohydrates7
1. Savin, Z., et al. (2018). Smoking and the intestinal microbiome. Archives of microbiology, 200(5), 677-684.
2. David, L. A., et al. (2014). Diet rapidly and reproducibly alters the human gut microbiome. Nature, 505(7484), 559.
3. Biesalski, H. K. (2016). Nutrition meets the microbiome: micronutrients and the microbiota. Annals of the New York Academy of Sciences, 1372(1), 53-64.
4. Albenberg, L. G., & Wu, G. D. (2014). Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology, 146(6), 1564-1572.
5. De Filippo, C., et al. (2010). Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proceedings of the National Academy of Sciences, 107(33), 14691-14696.
6. Huang, E. Y., et al. (2013). The role of diet in triggering human inflammatory disorders in the modern age. Microbes and Infection, 15(12), 765-774.
7. Sonnenburg, E. D., & Sonnenburg, J. L. (2014). Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. Cell metabolism, 20(5), 779-786.
L'influenza di dolcificanti e emulsionanti sul microbioma
Artificial sweeteners induce glucose intolerance by altering the gut microbiota.1
Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome.2Dietary emulsifiers—sweepers of the gut lining?3
1. Suez, J., et al. (2014). Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature, 514(7521), 181.
2. Chassaing, B., et al. (2015). Dietary emulsifiers impact the mouse gut microbiota promoting colitis and metabolic syndrome. Nature, 519(7541), 92.
3. Cani, P. D. (2015). Metabolism: Dietary emulsifiers—sweepers of the gut lining?. Nature Reviews Endocrinology, 11(6), 319.
L'influenza positiva della fibra alimentare sul microbioma
Fiber and Prebiotics: Mechanisms and Health Benefits.1
Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis.2
1. Slavin, J. (2013). Fiber and prebiotics: mechanisms and health benefits. Nutrients, 5(4), 1417-1435.
2. So, D., et al. (2018). Dietary fiber intervention on gut microbiota composition in healthy adults: a systematic review and meta-analysis. The American journal of clinical nutrition, 107(6), 965-983.
Probiotici
Cosa sono i probiotici e come funzionano?
Effects of Probiotics, Prebiotics, and Synbiotics on Human Health1
Probiotics: definition, scope and mechanisms of action.2Probiotic Mechanisms of Action.3Chapter 1 Understanding the Mechanisms by Which Probiotics Inhibit Gastrointestinal Pathogens.4Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation.5Identification of probiotic effector molecules: present state and future perspectives.6Protection and Restitution of Gut Barrier by Probiotics: Nutritional and Clinical Implications.7Probiotics: determinants of survival and growth in the gut.8
1. Markowiak, P., & Śliżewska, K. (2017). Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients, 9(9), 1021.
2. Reid, G. (2016). Probiotics: definition, scope and mechanisms of action. Best Practice & Research Clinical Gastroenterology, 30(1), 17-25.
3. Bermudez-Brito, M., et al. (2012). Probiotic mechanisms of action. Annals of Nutrition and Metabolism, 61(2), 160-174.
4. Corr, S. C., et al. (2009). Understanding the mechanisms by which probiotics inhibit gastrointestinal pathogens. Advances in food and nutrition research, 56, 1-15.
5. Hemarajata, P., & Versalovic, J. (2013). Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic advances in gastroenterology, 6(1), 39-51.
6. Lebeer, S., et al. (2018). Identification of probiotic effector molecules: present state and future perspectives. Current opinion in biotechnology, 49, 217-223.
7. Krishna Rao, R., & Samak, G. (2013). Protection and restitution of gut barrier by probiotics: nutritional and clinical implications. Current Nutrition & Food Science, 9(2), 99-107.
8. Bezkorovainy, A. (2001). Probiotics: determinants of survival and growth in the gut. The American journal of clinical nutrition, 73(2), 399s-405s.
Prebiotici ed estratti vegetali
Prebiotici
1. Gibson, G. R., et al. (2017). Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature reviews Gastroenterology & hepatology, 14(8), 491.
2. Gibson, G. R., & Roberfroid, M. B. (1995). Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. The Journal of nutrition, 125(6), 1401-1412.
3. Van Loo, J., et al. (1999). Functional food properties of non-digestible oligosaccharides: a consensus report from the ENDO project (DGXII AIRII-CT94-1095). British Journal of Nutrition, 81(2), 121-132.
4. Collins, S., & Reid, G. (2016). Distant site effects of ingested prebiotics. Nutrients, 8(9), 523.
5. Macfarlane, G. T., et al. (2008). Bacterial metabolism and health‐related effects of galacto‐oligosaccharides and other prebiotics. Journal of applied microbiology, 104(2), 305-344.
6. Al-Sheraji, S. Het al. (2013). Prebiotics as functional foods: A review. Journal of functional foods, 5(4), 1542-1553.
Inulina
Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin.1
Health Effects and Sources of Prebiotic Dietary Fiber.2A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.3
1. Gibson, G. Ret al. (1995). Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology, 108(4), 975-982.
2. Carlson, J. L., et al. (2018). Health effects and sources of prebiotic dietary fiber. Current developments in nutrition, 2(3), nzy005.
3. Guess, N. D., et al. (2015). A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & metabolism, 12(1), 36.
Polifenoli e il microbioma
Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition.1
Benefits of polyphenols on gut microbiota and implications in human health.2Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. 3Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention.4
1. Etxeberria, U., et al. (2013). Impact of polyphenols and polyphenol-rich dietary sources on gut microbiota composition. Journal of agricultural and food chemistry, 61(40), 9517-9533.
2. Cardona, F., Andrés-Lacueva, C., et al. (2013). Benefits of polyphenols on gut microbiota and implications in human health. The Journal of nutritional biochemistry, 24(8), 1415-1422.
3. Les, F., et al. (2018). Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of ethnopharmacology, 220, 67-74.
4. Thilakarathna, W. W., et al. (2018). Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention. Current Opinion in Food Science, 20, 51-57.
Radice di cicoria
1. Nishimura, M., et al. (2015). Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties. Journal of traditional and complementary medicine, 5(3), 161-167.
2. Atta, A. H., et al. (2010). Hepatoprotective effect of methanol extracts of Zingiber officinale and Cichorium intybus. Indian journal of pharmaceutical sciences, 72(5), 564.
3. Kleessen, B., et al. (2007). Jerusalem artichoke and chicory inulin in bakery products affect faecal microbiota of healthy volunteers. British Journal of Nutrition, 98(3), 540-549.
Melograno
1. Les, F., et al. (2018). Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of ethnopharmacology, 220, 67-74.
2. Andreux, P. A., et al. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 1(6), 595.
Dailybacs
Apparato digerente
Probiotics in the treatment of irritable bowel syndrome.1
The effect of probiotics as a treatment for constipation in elderly people: A systematic review.2The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study.3Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease.4In vitro sensitivity of probiotics to human pancreatic juice.5Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains.6Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli?7The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials.8Effect of Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers.9Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota.10The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the "gastric barrier effect" in patients chronically treated with PPI: a pilot study.11Clinical Uses of Probiotics.12A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6-month intervention.13A Randomized Controlled Trial of Lactobacillus GG in Children With Functional Abdominal Pain.14A randomized double-blind placebo-controlled trial of Lactobacillus GG for abdominal pain disorders in children.15Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota.16
1. Saggioro, A. (2004). Probiotics in the treatment of irritable bowel syndrome. Journal of clinical gastroenterology, 38, S104-S106.
2. Martínez-Martínez, M. I., et al. (2017). The effect of probiotics as a treatment for constipation in elderly people: A systematic review. Archives of gerontology and geriatrics, 71, 142-149.
3. Del Piano, M., et al. (2010). The use of probiotics in healthy volunteers with evacuation disorders and hard stools: a double-blind, randomized, placebo-controlled study. Journal of clinical gastroenterology, 44, S30-S34.
4. Klemenak, M., et al. (2015). Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Digestive diseases and sciences, 60(11), 3386-3392.
5. Del Piano, M., et al. (2008). In vitro sensitivity of probiotics to human pancreatic juice. Journal of clinical gastroenterology, 42, S170-S173.
6. Mogna, L., et al. (2012). Assessment of the in vitro inhibitory activity of specific probiotic bacteria against different Escherichia coli strains. Journal of clinical gastroenterology, 46, S29-S32.
7. Del Piano, M., et al. (2014). Correlation between chronic treatment with proton pump inhibitors and bacterial overgrowth in the stomach: any possible beneficial role for selected lactobacilli?. Journal of clinical gastroenterology, 48, S40-S46.
8. Dimidi, E., et al. (2014). The effect of probiotics on functional constipation in adults: a systematic review and meta-analysis of randomized controlled trials. The American journal of clinical nutrition, 100(4), 1075-1084.
9. Ogata, T., et al. (1997). Effect of Bifidobacterium longum BB536 administration on the intestinal environment, defecation frequency and fecal characteristics of human volunteers. Bioscience and Microflora, 16(2), 53-58.d controlled trials. The American journal of clinical nutrition, 100(4), 1075-1084.
10. Odamaki, T., et al. (2012). Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe, 18(1), 14-18.
11. Del Piano, M., et al. (2012). The innovative potential of Lactobacillus rhamnosus LR06, Lactobacillus pentosus LPS01, Lactobacillus plantarum LP01, and Lactobacillus delbrueckii Subsp. delbrueckii LDD01 to restore the “gastric barrier effect” in patients chronically treated with PPI: a pilot study.Journal of clinical gastroenterology, 46, S18-S26.
12. Islam, S. U. (2016). Clinical uses of probiotics. Medicine, 95(5).
13. Kajander, K., et al. (2005). A probiotic mixture alleviates symptoms in irritable bowel syndrome patients: a controlled 6‐month intervention. Alimentary pharmacology & therapeutics, 22(5), 387-394.
14. Francavilla, R., et al. (2010). A randomized controlled trial of Lactobacillus GG in children with functional abdominal pain. Pediatrics, 126(6), e1445-e1452.
15. Gawrońska, A., et al. (2007). A randomized double‐blind placebo‐controlled trial of Lactobacillus GG for abdominal pain disorders in children. Alimentary pharmacology & therapeutics, 25(2), 177-184.
16. Odamaki, T., et al. (2012). Effect of the oral intake of yogurt containing Bifidobacterium longum BB536 on the cell numbers of enterotoxigenic Bacteroides fragilis in microbiota. Anaerobe, 18(1), 14-18.
Cuore/Circolazione
Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial.1
Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties.2A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes.3Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol.4
1. Noad, R. L., et al. (2016). Beneficial effect of a polyphenol-rich diet on cardiovascular risk: a randomised control trial. Heart, 102(17), 1371-1379.
2. Nishimura, M., et al. (2015). Effects of the extract from roasted chicory (Cichorium intybus L.) root containing inulin-type fructans on blood glucose, lipid metabolism, and fecal properties. Journal of traditional and complementary medicine, 5(3), 161-167.
3. Guess, N. D., et al. (2015). A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & metabolism, 12(1), 36.
4. Andrade, S., & Borges, N. (2009). Effect of fermented milk containing Lactobacillus acidophilus and Bifidobacterium longum on plasma lipids of women with normal or moderately elevated cholesterol. Journal of dairy research, 76(4), 469-474.
Psiche
Efficacy of Probiotics on Anxiety: A Meta-analysis of Randomized Controlled Trials.1
Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study.2An Investigation of the Acute Effects of Oligofructose-Enriched Inulin on Subjective Wellbeing, Mood and Cognitive Performance.3The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.4A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial.5
1. Huang, R., et al. (2017). Efficacy of probiotics on anxiety: A meta-analysis of randomized controlled trials. Neuropsychiatry, 7(6), 862-871.
2. Kim, C. S., & Shin, D. M. (2019). Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study. Nutrition, 63, 169-174.
3. Smith, A., et al. (2015). An investigation of the acute effects of oligofructose-enriched inulin on subjective wellbeing, mood and cognitive performance. Nutrients, 7(11), 8887-8896.
4. Srikantha, P., & Mohajeri, M. H. (2019). The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. International journal of molecular sciences, 20(9), 2115.
5. Pärtty, A., et al. (2015). A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial. Pediatric research, 77(6), 823.
Cellule
Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities.1
Probiotic food consumption is associated with lower severity and prevalence of depression: A nationwide cross-sectional study.2
1. Amaretti, A., et al. (2013). Antioxidant properties of potentially probiotic bacteria: in vitro and in vivo activities. Applied microbiology and biotechnology, 97(2), 809-817.
2. Kerimi, A., & Williamson, G. (2016). At the interface of antioxidant signalling and cellular function: Key polyphenol effects. Molecular nutrition & food research, 60(8), 1770-1788.
Allergie
1. Drago, L., et al. (2015). Immunomodulatory effects of Lactobacillus salivarius LS01 and Bifidobacterium breve BR03, alone and in combination, on peripheral blood mononuclear cells of allergic asthmatics. Allergy, asthma & immunology research, 7(4), 409-413.
2. Manzotti, G., et al. (2014). Multi-strain Symbiotic Preparations as a Novel Adjuvant Approach to Allergic Rhinitis. Journal of Contemporary Immunology. 1. 67-80.
3. Enomoto, T., et al. (2014). Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergology International, 63(4), 575-585.
4. Xiao, J. Z., et al. (2006). Probiotics in the treatment of Japanese cedar pollinosis: a double‐blind placebo‐controlled trial. Clinical & Experimental Allergy, 36(11), 1425-1435.
5.Xiao, J. Z., et al. (2007). Clinical efficacy of probiotic Bifidobacterium longum for the treatment of symptoms of Japanese cedar pollen allergy in subjects evaluated in an environmental exposure unit. Allergology international, 56(1), 67-75.
Metabolismo
1.Les, F., et al. (2018). Pomegranate polyphenols and urolithin A inhibit α-glucosidase, dipeptidyl peptidase-4, lipase, triglyceride accumulation and adipogenesis related genes in 3T3-L1 adipocyte-like cells. Journal of ethnopharmacology, 220, 67-74.
2. Ryu, D., et al. (2016). Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature medicine, 22(8), 879.
3. Thilakarathna, W. W., et al. (2018). Polyphenol-based prebiotics and synbiotics: potential for cancer chemoprevention. Current Opinion in Food Science, 20, 51-57.
4. Andreux, P. A., et al. (2019). The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans. Nature Metabolism, 1(6), 595.
5.Guess, N. D., et al. (2015). A randomized controlled trial: the effect of inulin on weight management and ectopic fat in subjects with prediabetes. Nutrition & metabolism, 12(1), 36.
6. Minami, J. I., et al. (2015). Oral administration of Bifidobacterium breve B-3 modifies metabolic functions in adults with obese tendencies in a randomised controlled trial. Journal of nutritional science, 4.
7. Minami, J., et al. (2018). Effects of Bifidobacterium breve B-3 on body fat reductions in pre-obese adults: a randomized, double-blind, placebo-controlled trial. Bioscience of microbiota, food and health, 18-001.
8.Mogna, L., et al. (2014). Screening of different probiotic strains for their in vitro ability to metabolise oxalates: any prospective use in humans?. Journal of clinical gastroenterology, 48, S91-S95.
Sistema immunitario
A new chance of preventing winter diseases by the administration of synbiotic formulations.1
Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease.2Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community.3Interaction between probiotics and human immune cells.4Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach.5
1. Pregliasco, F., et al. (2008). A new chance of preventing winter diseases by the administration of synbiotic formulations. Journal of clinical gastroenterology, 42, S224-S233.
2. Klemenak, M., et al. (2015). Administration of Bifidobacterium breve Decreases the Production of TNF-α in Children with Celiac Disease. Digestive diseases and sciences, 60(11), 3386-3392.
3. Sugahara, H., et al. (2015). Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community. Scientific reports, 5, 13548.
4. Nicola, S., et al. (2010). Interaction between probiotics and human immune cells. Focus Diet. Fibres Pre/Probiot, 21, 9-12.
5. Mogna, L., et al. (2018). Micronized Cells of the Probiotic Strain Bifidobacterium lactis BS01 Activate Monocyte Polarization: A New Approach. Journal of clinical gastroenterology, 52, S57-S61.
Pelle
Probiotics as a novel adjuvant approach to atopic dermatitis.1
Probiotics reduce gut microbial translocation and improve adult atopic dermatitis.2Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota.3
1. Manzotti, G., et al. (2014). Probiotics as a Novel Adjuvant Approach to Atopic Dermatitis. Journal of Contemporary Immunology, 1. 57-66.
2. Lemoli, E., et al. (2012). Probiotics reduce gut microbial translocation and improve adult atopic dermatitis. Journal of clinical gastroenterology, 46, S33-S40.
3. Enomoto, T., et al. (2014). Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergology International, 63(4), 575-585.
Bocca e denti
1. Del Piano, M., et al. (2014). Correlation between Specific Bacterial Groups in the Oral Cavity and the Severity of Halitosis: Any Possible Beneficial Role for Selected Lactobacilli. J Gastroint Dig Syst, 4(197), 2.
2.Näse, L., et al. (2001). Effect of long–term consumption of a probiotic bacterium, Lactobacillus rhamnosus GG, in milk on dental caries and caries risk in children. Caries research, 35(6), 412-420.
Vescica
1. Vicariotto, F. (2014). Effectiveness of an association of a cranberry dry extract, D-mannose, and the two microorganisms Lactobacillus plantarum LP01 and Lactobacillus paracasei LPC09 in women affected by cystitis: a pilot study. Journal of clinical gastroenterology, 48, S96-S101.
Donne
1. Holloway, L., et al. (2007). Effects of oligofructose-enriched inulin on intestinal absorption of calcium and magnesium and bone turnover markers in postmenopausal women. British Journal of Nutrition, 97(2), 365-372.
2. de Brito Alves, J. L., et al. (2019). Gut microbiota and probiotic intervention as a promising therapeutic for pregnant women with cardiometabolic disorders: present and future directions. Pharmacological research, 104252.
3. Han, M. M., et al. (2019). Probiotics improve glucose and lipid metabolism in pregnant women: a meta-analysis. Annals of translational medicine, 7(5).
4. Reid, G. (2016). The development of probiotics for women’s health. Canadian journal of microbiology, 63(4), 269-277.
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Bambini
Edible Plants and Their Influence on the Gut Microbiome and Acne.1
Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection.2 The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder.3 A combination of prebiotic short- and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents.4Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: a comparison between one-species and three-species administration.5
1. Clark, A. K., et al. (2017). Edible plants and their influence on the gut microbiome and acne. International journal of molecular sciences, 18(5), 1070.
2. Li, K. L., et al. (2019). Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection. World Journal of Pediatrics, 1-7.
3. Srikantha, P., & Mohajeri, M. H. (2019). The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder. International journal of molecular sciences, 20(9), 2115.
4. Abrams, S. A., et al. (2005). A combination of prebiotic short-and long-chain inulin-type fructans enhances calcium absorption and bone mineralization in young adolescents–. The American journal of clinical nutrition, 82(2), 471-476.
5. Ishizeki, S., et al. (2013). Effect of administration of bifidobacteria on intestinal microbiota in low-birth-weight infants and transition of administered bifidobacteria: a comparison between one-species and three-species administration. Anaerobe, 23, 38-44.